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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis

Fig. 5

Dysregulation of complement components in tibialis anterior muscle of TDP-43Q331K mice at three different ages of disease progression. af The mRNA expression profiles of the following complement components: C1qB (a, classical pathway), C4 (b, classical/lectin pathway), fB (c, alternative pathway), C3 (d, central component), CD55 (e, regulator) and CD59a (f, regulator) in tibialis anterior muscle of TDP-43Q331K mice (blue bars) relative to non-transgenic (NTg, orange bars) and TDP-43WT (green bars) mice during 3, 10 and 16 months of age. g The protein expression of C5a in the tibialis anterior muscle of NTg (orange bars), TDP-43WT (green bars) and TDP-43Q331K (blue bars) mice at 16 months. h mRNA expression of C5aR1 in the tibialis anterior muscle of TDP-43Q331K mice relative to age-matched NTg and TDP-43WT mice at three different ages. Data are expressed as means ± SEM (n = 5 mice/group, *P < 0.05, **P < 0.01, ***P < 0.001, one-way ANOVA with Tukey’s post hoc test for each age)

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