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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis

Fig. 6

Motor dysfunction in TDP-43Q331K mice strongly correlates with lumbar spinal cord/tibialis anterior muscle levels of C1qB, C3 and C5aR1. A strong negative correlation between lumbar spinal cord mRNA expression of C1qB (a, r = − 0.6824), C3 (b, r = − 0.8282) and C5aR1 (c, r = − 0.7428) with hind-limb grip strength of non-transgenic (NTg), TDP-43WT and TDP-43Q331K mice, where C3 demonstrated the strongest correlation (n = 30, ****P < 0.0001, Pearson correlation). A moderate to strong negative correlation between tibialis anterior muscle mRNA levels of C1qB (d, r = − 0.6624) and C5aR1 (f, r = − 0.4116) with hind-limb grip strength of NTg, TDP-43WT and TDP-43Q331K mice, whereas a moderate positive correlation between C3 mRNA levels (e, r = 0.4149) was observed (n = 25, *P < 0.05, ***P < 0.001, Pearson correlation). Pearson correlation coefficient was used to measure the strength of the linear relationship between complement mRNA expression and hind-limb grip strength

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