Fig. 3

Global deletion of receptors controlling macrophage phenotype profoundly alters survival after endotoxin challenge. Gehan–Breslow–Wilcoxon survival analysis of mice administered 50 mg/kg LPS i.p. and euthanized at the humane endpoint of loss of self-righting reflex or censored at 48 h if still alive. Ifngr1^−/− mice demonstrate longer survival (p = 0.046) and Il10rb^−/− (p < 0.0001) and Il4ra^−/− (p = 0.014) have a shorter survival than corresponding WT. BALB/cJ survived slightly longer than C57BL/6J (p = 0.031). Il10rb^−/−, and Ifngr1^−/− mice were on a C57BL/6J background; and Il4ra^−/− on a BALB/cJ background. N = 10–17/strain. *Significantly different survival from WT; **significantly different survival between WT strains (p < 0.05)