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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Temporal changes in macrophage phenotype after peripheral nerve injury

Fig. 6

Macrophage phenotype influences gene expression of neurotrophic and growth factors relevant to peripheral nerve repair. Pro-inflammatory macrophages have higher expression of pro-angiogenic growth factors: Vegfa is consistently upregulated by IFNγ+LPS stimulation, while Pdgfb is downregulated by IL4 stimulation. Insulin-like growth factors, Igf1 and Igf2 are upregulated by IL4. Plot of gene expression Log2(fold change) over the unstimulated M(−) condition for BMDM of 5 strains of mice exposed to IL4 or IFNγ+LPS stimulation. n = 4–5/group

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