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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Temporal changes in macrophage phenotype after peripheral nerve injury

Fig. 8

Deletion of Il4ra or Ifngr1 does not alter the quality of reinnervation. A representative image of a retrograde labeled spinal cord in shown (a) with red dots denoting counted cells. The total number of retrograde labeled motor neurons per mouse 8 weeks after sciatic nerve transection and repair are shown (b, c). Il4ra−/− and control BALB/cJ mice underwent sciatic transection and empty conduit repair with a 3 mm gap (b). Ifngr1fl/fl cre/− and control mice underwent sciatic transection and direct coaptation (c). The cranial tibial muscle weights of the injured limb normalized to the contralateral limb 8 weeks after sciatic nerve transection and repair are shown (d, e). No differences were detected between strains or sexes. n = 6/sex/strain, except male Ifngr1fl/fl cre/− and control (n = 18 each). ANOVA (p > 0.05)

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