Fig. 3

CX3CL1 expression in abluminal media (M2) from WT and AD BBB models at the ages of 3 months (n = 5 for WT and AD), 6 months (n = 10 for WT, n = 8 for AD), and 12 months (n = 10 for WT, n = 5 for AD). CX3CL1 levels were analyzed by the 1-plex Luminex® xMAP® assay as described in the “Methods” section and expressed in picograms per millilitre. The mean is represented by a colored line following the origin of cell types (blue for WT and red for AD cells, respectively). ^*P < 0.05 in AD BBB model at 12 months compared to AD BBB models at 3 months by a Kruskal-Wallis test with a Dunn’s multiple comparison test