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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury

Fig. 7

The anti-inflammatory marker, CD206, is highly expressed in CD68+ macrophages in the WT DRG 3 and 7 days after sciatic nerve transection. Immunohistochemical labeling of DRG sections with antibodies against a macrophage marker, CD68, and an anti-inflammatory marker, CD206, shows that a majority of macrophages in the WT DRG at 7 days post injury express CD206 (k). The number of CD68+ and CD206+ cells was significantly diminished in Ccr2−/− mice at 3 days (f) and 7 days (k) post injury. Cell counts were performed using ImageJ at 1, 3, and 7 days post injury for CD68+-, CD206+-, and CD68+CD206+-colocalized cells (a, f, k). The counts represent the sum of cells from three images per section. Representative images of IHC staining in the L5 DRG at 1, 3, and 7 days post axotomy are shown for WT sham (b, g, l), WT Ax (c, h, m), Ccr2−/− sham (d, i, n), and Ccr2−/− Ax (e, j, o). All images were taken at × 25 magnification. Scale bar = 50 μm. n = 5 per group. *p < 0.05. **p < 0.001

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