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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades

Fig. 11

Effect of CM-MSC on pain-like behaviors of mice with diabetic neuropathy. a Mechanical nociceptive thresholds: ordinates represent the filament weight (g) in which the animal responds in 50% of presentations. b Thermal nociceptive threshold: the axis of ordinates represents the time (seconds) the animal takes to withdraw its paw. The nociceptive thresholds were assessed in the paw of each mouse before (b) and after the model induction with streptozotocin (STZ; week 0). Control group represents mice without diabetic neuropathy, in which saline was administered instead of streptozotocin. Four weeks after induction, mice were treated via endovenous route with conditioned medium from MSC cultures (STZ + CM-MSC; 100 μL) or vehicle (STZ + vehicle; 100 μL). Data are expressed as means ± SEM; n = 6 mice per group. *Statistical significance relative to the control group (p < 0.001). #Statistical significance relative to the STZ + vehicle group (p < 0.001), as determined by two-way ANOVA followed by Bonferroni post-test

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