Fig. 4
Effects of MSC on morphology and morphometry of C fibers of the sciatic nerve from mice with diabetic neuropathy. Electron microscopy of sciatic nerve cross-sections from non-diabetic mice (panel a, control), diabetic mice treated with saline (panel b, STZ + saline), and diabetic mice treated with MSC (1 × 106 panel c; STZ + MSC), performed 12 weeks after neuropathy induction. Scale bar = 0.5 μm. Ultrastructural analysis of the sciatic nerve showed the effects of MSC treatment on the area (panel d and density (panel e) of the fiber C of the sciatic nerve of mice with diabetic peripheral neuropathy. Data are expressed as means ± SEM; n = 3 mice per group. *Statistical significance compared to control group (p < 0.05). #Statistical significance compared to STZ + saline group (p < 0.05). One-way ANOVA followed by Tukey post-test