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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades

Fig. 9

MSC transplantation reduces galectin-3 expression in the dorsal horn of the spinal cord of neuropathic mice. Eight weeks after the treatment with MSC (1 × 106; STZ + MSC) or saline (STZ + saline), the galectin-3 (Gal-3) expression in the spinal cord of neuropathic mice was evaluated. Control non-diabetic group received saline instead of streptozotocin. Representative photomicrographs of spinal cord sections co-stained with Gal-3 and GFAP (ac) or Gal-3 and Iba-1 (df) (200×). Insets (400×) evidenced the presence of co-staining for Gal-3 and Iba1 (e) in saline-treated diabetic mice and the absence of Gal-3 and GFAP co-stained cells (ac). Scale bar = 50 μm. Panel g shows the quantitative analysis of the percentage area Gal-3 positive in the spinal dorsal horn. Data are expressed as means ± SEM; n = 3 mice per group. *Statistically significant as compared to the control group (p < 0.05). #Statistically significant as compared to the STZ + saline group (p < 0.05). One-way ANOVA followed by Tukey’s multiple comparison test

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