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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption

Fig. 5

CORM-3 increases the expression of ZO-1 and laminin on day 3 after cerebral infarction. a Representative images show double immunofluorescence staining of CD31/ZO-1-positive cells in peri-infarction zones. Insets show high-magnification images of the boxed areas. Scale bar = 50 μm. b Quantification of ZO-1-positive area/CD31-positive area in peri-infarction zones (*p < 0.05, n = 8 per group). c Representative images show double immunofluorescence staining of CD31/laminin-positive cells in peri-infarction zones. Insets show high-magnification images of the boxed areas. Scale bar = 50 μm. d Quantification of laminin-positive area/CD31-positive area in peri-infarction zones (*p < 0.05, n = 8 per group). e Representative Western blot of ZO-1 and laminin expression in the right hemisphere of each group. f, g Quantification of the Western blot analysis (*p < 0.05 vs. Sham + saline group, #p < 0.05 vs. tMCAO + CORM-3 group, n = 10 per group). Data are shown as mean ± SD

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