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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma

Fig. 10

Evans blue fluorescence and caveolin immunoreactivity in the brain following partial optic nerve transection. Lack of Evans blue fluorescence in a representative image of the periventricular region of the brain at 3 days after partial optic nerve transection (a), compared to strongly positive fluorescence at the partial optic nerve injury site 7 days after injury (b). Evans blue fluorescence in optic nerve 28 days after injury (c) was not different from uninjured controls injected with Evans blue (d). Caveolin immunoreactivity in endothelial cells lining the ventricles at 3, 7, 14, and 28 days after injury (e), scale = 100 μm. Mean ± SEM proportion of the ventricle lined with caveolin-1+ cells (f). n = 7–12. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001

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