Fig. 11

Preventive but not therapeutic treatment improves clinical outcome in PLPmut mice. a Accelerating rotarod performance of Wt, PLPmut, and PLPmut mice which received long-term preventive treatment. Treatment significantly improved latency to fall. b Accelerating rotarod performance of PLPmut mice which received therapeutic treatment for 5 months. Treatment failed to significantly improve latency to fall, most likely due to already progressed neurodegeneration at 10 months of age, when therapeutic treatment started. One-way ANOVA and Tukey’s post hoc tests. *P < 0.05, **P < 0.01. n = 5 mice per group