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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production

Fig. 5

Co-infection increased SAA and Fpr2 expression in the hypothalamus. Serum levels of a TNFα, b IL-1β, c IL-6 and d SAA from mice treated with saline (SAL), S. pneumoniae (SP), influenza A virus (IAV) or co-infection (SPIAV). Gene expression of e SAA1 and f Fpr2 in the hypothalamus. g–h Representative immunohistochemical images of SAA staining in the PVN region of the brain. Arrows denote the vasculature. n = 4–6; *p < 0.05, one-way ANOVA compared to SAL; #p < 0.05, one-way ANOVA compared to IAV

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