Table 1 Role of Nec-1 in neurodegenerative diseases
From: Necroptosis: a regulated inflammatory mode of cell death
S. no. | Neurodegenerative disease | Role of Nec-1 | References |
|---|---|---|---|
1 | Alzheimer’s disease | Nec-1 promotes the neural cell death and improves neurobehavior in Al-treated mice model. Nec-1 also ameliorates cognitive dysfunction, significantly reducing the level of Aβ and tau in APP/PS1 mice model. | |
2 | Parkinson’s disease | Nec-1 enhanced the cell survival in 6-OHDA-treated PC12 cells | [108] |
3 | Huntington’s disease | Nec-1 increased survival rate in ST14 8plx cells | [100] |