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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

Fig. 2

The expression of NLRP3 protein was decreased in the liver by siRNA administration in vivo without effects on brain or BMDM. a Immunofluorescence staining for GFP in the liver with × 10 objective, bar 200 μm. b Analysis of the NLRP3 and the GFP expression in liver samples from the siRNA negative control with the lentivirus (LV3-NC) or the Nlrp3 siRNA with the GFP (LV3-siNlrp3-GFP) mice via the tail vein. c Analysis of NLRP3 and GFP expression in the midbrain samples from the LV3-NC or the LV3-siNlrp3-GFP mice via the tail vein. d Analysis of NLRP3 and GFP expression in the BMDM samples from the LV3-NC or the LV3-siNlrp3-GFP mice via the tail vein (n = 4 animals per condition). Samples were collected after 7 days of last saline injection. Data is presented as mean ± SEM, Student’s T test, ***p < 0.001 versus the LV3-NC group

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Journal of Neuroinflammation

ISSN: 1742-2094