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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE

Fig. 2

CXCL2 is produced by CD45+ cells in the brainstem infiltrates during aEAE. a Brainstem tissue was harvested from an IFNγRKO host at aEAE onset (clinical score 1). Sections were subjected to in situ hybridization to detect CXCL2 mRNA (red) combined with a DAPI (blue) counter stain. b Brainstem sections from a mouse with aEAE (clinical score 3) were stained with monoclonal antibodies specific for CD45 (green), GFAP (white), and CXCL2 (red) and counterstained with DAPI (blue). Arrows indicate CXCL2+ CD45+ cells. Arrow heads indicate GFAP+ astrocytes

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