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Table 1 IFNgR deficiency in Lysozyme M (LysM)-expressing myeloid cells increases susceptibility to EAE

From: An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE

Genotype

Incidence of aEAE

Average cumulative clinical score aEAE

Incidence of cEAE

Average cumulative clinical score cEAE

Cre−

4/13 (30.8%)

10.5 ± 1.11

9/13 (69.2%)

26.7 ± 1.93

Cre+

16/26 (61.5%)

6.44 ± 0.226

18/26 (69.2%)

32.4 ± 1.04

  1. LysM-Cre:IFNgRflox/flox mice and their non-Cre expressing littermates were injected with MOG35–55-reactive encephalitogenic Th1 cells. Mice were evaluated for signs of aEAE or cEAE on a daily basis by examiners blinded to group identity
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Journal of Neuroinflammation

ISSN: 1742-2094