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Table 1 IFNgR deficiency in Lysozyme M (LysM)-expressing myeloid cells increases susceptibility to EAE

From: An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE

Genotype Incidence of aEAE Average cumulative clinical score aEAE Incidence of cEAE Average cumulative clinical score cEAE
Cre− 4/13 (30.8%) 10.5 ± 1.11 9/13 (69.2%) 26.7 ± 1.93
Cre+ 16/26 (61.5%) 6.44 ± 0.226 18/26 (69.2%) 32.4 ± 1.04
  1. LysM-Cre:IFNgRflox/flox mice and their non-Cre expressing littermates were injected with MOG35–55-reactive encephalitogenic Th1 cells. Mice were evaluated for signs of aEAE or cEAE on a daily basis by examiners blinded to group identity