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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury

Fig. 3

Ex vivo biodistribution of DiR-labeled exosomes after TBI. a Imaging revealed exosomes migrating to the spleen, liver, and lungs 1 h after transplantation and migrating to the impact site of the brain on day 3 after TBI relative to sham controls. Ex vivo analysis shows the fluorescent signal intensity was highest in the spleen and liver 1 h after transplantation and gradually declined through day 11, whereas the lungs slightly increased at day 3 before declining through days 7 and 11. The brain impact site showed no apparent signal when compared to TBI-sham treatment animals 1 h after exosome transplantation, but increased by day 3 where the signal remained through day 7 and only TEdM radiant efficiency declined by day 11. b Radiant efficiency is expressed as photons per second per square centimeter per steridian divided by microwatts per square centimeter(((p/s)/ 〖 cm) ^ 2/sr)/(μW/ 〖 cm) ^ 2 )). Data represent the mean ± SEM values N = 3 per group

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