Fig. 4

Hierarchical heat map of gene expression of (a) coding genes or (b) noncoding RNA from the RNA Seq dataset. The gene clustering from the spleen is on the top, and brain is the lower half of the dendrograms. For both a and b, RPKM data from 19,058 detectable rat genes were used in analysis by hierarchical clustering with Gene Cluster 3.0. RPKMs were log-2-transformed and adjusted by centering genes using the median. Clustering was performed on genes and arrays using centered correlation as distance measure and average linkage as method. Data shows clusters of genes or noncoding RNA that are affected by TBI and restored towards the no TBI pattern with exosome treatment