Table 2 Canonical pathways

 Pattern 1

  Pancreatic adenocarcinoma signaling

  Role of CHK proteins in cell cycle checkpoint control

  T helper cell differentiation

  Cyclins and cell cycle regulation

  Th1 pathway

  Bladder cancer signaling

  Inhibition of angiogenesis by TSP1

  Dopamine receptor signaling

  ILK signaling

  B cell development

  Cell cycle regulation by BTG family proteins

  Inhibition of matrix metalloproteases

  Thyroid cancer signaling

  HIF1α signaling

  Crosstalk between dendritic cells and natural killer cells

  Th1 and Th2 activation pathway

  Role of JAK family kinases in IL-6-type cytokine signaling

  Role of JAK1 and JAK3 in γc cytokine signaling

  Role of Oct4 in mammalian embryonic stem cell pluripotency

  Autoimmune thyroid disease signaling

 Pattern 1

 Pattern − 1

  Heme biosynthesis II

  cAMP-mediated signaling

  Mitotic roles of polo-like kinase

  G-Protein coupled receptor signaling

  Heme biosynthesis from uroporphyrinogen-III I

  Serine biosynthesis

  Tetrapyrrole biosynthesis II

  Superpathway of serine and glycine biosynthesis I

  Estrogen-mediated S-phase entry

  LPS/IL-1-mediated inhibition of RXR function

  GADD45 signaling

  Protein kinase A signaling

  Cell cycle: G2/M DNA damage checkpoint regulation

  Cardiac hypertrophy signaling

  Cyclins and cell cycle regulation

  Fatty acid activation

  dTMP de novo biosynthesis

  nNOS signaling in skeletal muscle cells

  Cell cycle control of chromosomal replication

  Corticotropin releasing hormone signaling

  DNA damage-induced 14-3-3σ signaling

  Rapoport-Luebering glycolytic shunt

  Pyrimidine deoxyribonucleotides de novo biosynthesis I

  ATM signaling

  Antiproliferative role of TOB in T cell signaling

  Role of CHK proteins in cell cycle checkpoint control

  Cell cycle: G1/S checkpoint regulation

  Cell cycle regulation by BTG family proteins

  Asparagine biosynthesis I

  γ-Glutamyl cycle