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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain

Fig. 3

Effect of Bindarit and RS504393 on ethanol-induced apoptotic neuronal death in the developing mouse brain. Bindarit (100 mg/kg) or RS504393 (1 mg/kg) was administered by two subcutaneous (SC) injections at 24 and 0.5 h prior to EtOH exposure as described in the “Methods” section. 8 h after EtOH injection, the pups were sacrificed and the brains were harvested. The expression of cleaved caspase-3 in the cerebral cortex (CTX) and cerebellum (CB) was determined by IB and quantified by the normalization to actin. Each data point was the mean ± SEM of six animals. *p < 0.05, statistically significant difference from control group; # p < 0.05, statistically significant difference from EtOH-treated group

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