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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition

Fig. 3

Chronic Toxoplasma infection reduces synaptic protein expression in the whole brain. a Immunoblot analysis from brain homogenate in the neocortex and hippocampus for glutamatergic synaptic proteins. Relative protein levels of glutamate transporter EAAT2, postsynaptic scaffolding protein Shank3, and glutamate receptors GluA1, GluA2, GluN1, and GluN2B were quantified. b revealed downregulation of EAAT2, Shank3, GluA1, GluA2, and GluN1 in the hippocampus. c Data also revealed downregulation of EAAT2, Shank3, GluA1, GluN1, and GluN2B in the cortex of homogenate. Control mice (CTRL) n = 8, infected mice (INF) n = 8. Displayed results are mean values ± SEM. ****p < 0.00001, ***p < 0.001, **p < 0.01, *p < 0.05

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