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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition

Fig. 7

Sulfadiazine treatment is associated with reduced Toxoplasma-tachyzoite levels as well as abated neuroinflammatory response. a Quantitative real-time PCR (qRT-PCR) was performed on sulfadiazine-treated brain samples. Treatment-related changes in the expression of IFN-γ, IL-12, IL-10, TNF, IL-6, and IL-1β were compared to infected mice (INF) n = 9; infected, sulfadiazine-treated mice (INF + Sulfa) n = 9. b Quantitative real-time PCR (qRT-PCR) from indicated brain samples. Treatment related changes for SAG1 were also observed for day 10, day 20, and day 35. SAG1-tachyzoite surface antigen 1. Infected mice (INF) n = 4; infected, sulfadiazine-treated mice (INF + Sulfa) n = 4. c Time course for cyst enumeration in infected and sulfadiazine-treated brain samples after infection for 10, 20, or 35 days. Infected mice (INF) n = 3; infected, sulfadiazine-treated mice (INF + Sulfa) n = 4. Displayed results are mean values ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001

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