Fig. 6

Splenectomy alters the acute effects of early intravenous MSCs infusion following SCI. When HUCMCs were intravenously infused (via tail vein) at 1 h post-SCI, there was a significant reduction in lesion volume, parenchymal hemorrhage, and plasma IL-10 at 1 day following cell transplant compared to the vehicle control (a). Data are expressed as percent mean ± SEM (n = 4 per group), unpaired t test, ∗p ≤ .05. When the experiment was repeated in the absence of a spleen (splenectomy), some of HUCMC-mediated effects at 1 day post-SCI were lost (b). Data are expressed as percent mean ± SEM (n = 4–5 per group), and unpaired t test performed (between HUCMCs and vehicle controls), ∗p ≤ .05