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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation

Fig. 6

Activating GPR30 relieved microglial activation. a Low-magnification micrographs showing microglial cells in ischemic penumbra 24 h after reperfusion. The yellow dotted ring shows the ischemic penumbra area that was addressed. Scale bar = 500 μm. b Representative immunofluorescence images showing the morphologies of the microglia cells labeled with Iba1 and TLR4 in microglia 24 h after reperfusion. Scale bar = 20 μm. c The average area of single microglial cells labeled by Iba1 and TLR4 in the ischemic penumbra. The data are expressed as the mean ± SD and analyzed by one-way ANOVA with Tukey’s post-test. #p < 0.05, ####p < 0.0001 compared with the sham group. *p < 0.05, ***p < 0.001 compared with the vehicle group. n = 6 per group. Five brain sections were analyzed per animal

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