Fig. 3
From: Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis
S-NFL and CSF-NFL and separation of patients with and without disease activity during follow-up. Receiver operating characteristics (ROC) curves for baseline a S-NFL and b CSF-NFL and separation of patients with and without disease activity during follow-up after 1 (purple), 2 (blue), and 4 (black) years. Disease activity was defined as relapses, brain MRI activity (new or enlarging T2 lesions or Gd-enhancing lesions), or disability worsening. With a cutoff level of 450 ng/L for baseline CSF-NFL, sensitivity for identifying disease activity was 95% at 1 year, 93% at 2 years, and 81% at 4 years, with specificity 50, 67, and 57%, respectively. With a cutoff level of 14.2 ng/L for baseline S-NFL, sensitivity for identifying disease activity was 76% at 1 year, 74% at 2 years, and 72% at 4 years, with specificity 50, 50, and 57%, respectively