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Table 3 Correlations between neuroinflammatory and neurodegenerative markers, baseline number of T2 lesions, number of new T2 lesions, and BPF change during follow-up

From: Neurofilament levels, disease activity and brain volume during follow-up in multiple sclerosis

 

T2,

BL

New T2,

1 year

New T2,

2 years

New T2,

4 years

BPF change,4 years

S-NFL, BL

0.33

0.55*

0.43

0.44

− 0.24

S-NFL, 1y

0.45

0.43

0.33

0.34

− 0.56*

S-NFL, 2y mean

0.45

0.52*

0.37

0.37

− 0.37

S-NFL, 4y mean

0.41

0.43

0.32

0.35

−0.42

CSF-NFL, BL

0.29

0.60*

0.64*

0.51*

− 0.20

CSF-NFL, 1y

0.59*

0.59*

0.58*

0.50*

− 0.54*

CSF-NFL, 2y mean

0.43

0.62*

0.65

0.54

−0.33

CSF-NFL, 4y mean

0.41

0.55*

0.60*

0.53*

− 0.35

MMP-9, BL

0.46

0.53*

0.47

0.42

− 0.16

MMP-9, mean

0.38

0.51*

0.51*

0.46

−0.26

CHI3L1, BL

0.49

0.42

0.36

0.26

−0.55*

CHI3L1, 1y

0.45

0.35

0.30

0.30

− 0.60*

CHI3L1, 2y

0.31

0.13

0.11

0.13

− 0.50*

CHI3L1, mean

0.42

0.30

0.24

0.20

− 0.54*

OPN, BL

0.51*

0.34

0.21

0.23

− 0.52*

CXCL1, BL

0.51*

0.56*

0.42

0.23

− 0.34

CXCL10, BL

0.50*

0.58*

0.48

0.41

− 0.26

CXCL10, mean

0.47

0.51*

0.42

0.34

− 0.37

CXCL13, BL

0.37

0.51*

0.52*

0.46

− 0.26

CXCL13, mean

0.40

0.49

0.52*

0.45

− 0.33

CCL22, mean

0.29

0.49

0.57*

0.54*

− 0.31

T2, BL

1.00

0.48

0.39

0.27

− 0.56*

New T2, 1y

0.48

1.00

0.86*

0.66*

− 0.44

New T2, 2y

0.39

0.86*

1.00

0.83*

− 0.47

New T2, 4y

0.27

0.66*

0.83*

1.00

− 0.36

BPF decrease, 4y

− 0.56*

− 0.44

− 0.47

− 0.36

1.00

  1. Magnitude of correlation coefficients (Spearman’s rho) from bivariate non-parametric correlation analyses (Spearman) are shown
  2. 2y mean refers to the mean of levels at baseline, 1-year, and 2-year follow-up
  3. 4y mean refers to the mean of levels at baseline, 1-year, 2-year, and 4-year follow-up
  4. T2, BL: number of T2 lesions in baseline brain MRI
  5. New T2, 1y, 2y and 4y: number of new T2 lesions in brain MRI during 1, 2, and 4 years of follow-up, respectively, compared to baseline MRI
  6. BPF change, 4y: brain parenchymal fraction decrease during 4 years of follow-up
  7. S serum, CSF cerebrospinal fluid, BL baseline
  8. *Spearman’s rho ≥ 0.50 and p ≤ 0.001
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Journal of Neuroinflammation

ISSN: 1742-2094