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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

Fig. 8

Schematic diagram of the effects of Nogo/NgR pathway on microglial adhesion and migration to fAβ. The interaction of Nogo with NgR enhanced activity of RhoA and phosphorylation of MLC and cofilin and decreased activity of Rac1 and Cdc42 and expression of IQGAP, which regulated cytoskeleton arrangement. Then, adhesion and migration of microglia to fAβ was decreased. Moreover, expression of CD36 in microglia was decreased by the Nogo/NgR pathway, which might also contribute to the downregulation of microglial adhesion and migration to fAβ

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Journal of Neuroinflammation

ISSN: 1742-2094