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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Fig. 3

Effects of MPTP on Cx43 expression in the striatum of WT and Cx30 KO mice on days 1 and 7 after the treatment with normal saline (NS) or MPTP. a, b Number of Cx43-immunoreactive dots counted by Nikon NIS-Element software. c, d, qRT-PCR analysis of Cx30 mRNA levels normalised to Gapdh mRNA. e, f Cx30 protein levels measured by Western blotting and normalised to β-actin levels. Analyses were performed on day 1 (a, c, e) and day 7 (b, d, f) after treatment. Data are presented as the mean ± SEM of n = 4–5 mice per group. *p < 0.05 and ***p < 0.001 by two-way ANOVA followed by the Tukey–Kramer post hoc test. Blot images are presented in Additional file 1: Figure S2

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Journal of Neuroinflammation

ISSN: 1742-2094