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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Fig. 5

Acceleration of MPTP-induced nigrostriatal damage by Cx30 deficiency. WT and Cx30 KO mice were injected with normal saline (NS) or MPTP, and mice were analysed 7 days later. a, b TH immunostaining of the striatum (a) and the SNc (b) in scale bars a 50 μm and b 100 μm. c, d TH-positive fibre density in the striatum (c) and number of TH-positive cells in the SNc (d). e Concentrations of dopamine and its metabolites DOPAC and HVA in the striatum. The experiment to examine the MPTP-induced acceleration of DA neuron death was repeated three times, and essentially, the same results were obtained. Data are presented as the mean ± SEM of n = 4 mice per group. *p < 0.05, **p < 0.01, and ***p < 0.001 by two-way ANOVA followed by the Tukey–Kramer post hoc test (c, d) or Dunnett’s t test (e)

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Journal of Neuroinflammation

ISSN: 1742-2094