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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Fig. 7

Alteration of S100a10 and Gdnf expression in the striatum by Cx30 deficiency. WT and Cx30 KO mice were injected with normal saline (NS) or MPTP, and mice were analysed 1 and 7 days later. a, b RT-PCR analysis of S100a10 mRNA levels normalised to Gapdh mRNA. c, d RT-PCR analysis of Gdnf mRNA levels normalised to Gapdh mRNA. e ELISA analysis of GDNF protein levels. Analyses were performed on days 1 (a, c, e) and 7 (b, d) after treatment. Data are expressed as the mean ± SEM of n = 4–5 mice per group. N.S., not significant; *p < 0.05, **p < 0.01, and ***p < 0.001 by two-way ANOVA followed by the Tukey–Kramer post hoc test

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Journal of Neuroinflammation

ISSN: 1742-2094