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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Fig. 8

Expression of Gdnf and S100a10 mRNA in S100β-positive astrocytes. Left panels: Gdnf (a) and S100a10 (b) in situ hybridisation (blue colour) combined with S100β immunohistochemistry (brown colour) in the striatum of WT and Cx30 KO mice 1 day after injection of normal saline (NS) or MPTP. Gdnf and S100a10 mRNA expression (yellow arrowheads) colocalise with S100β-positive astrocytes. Black boxes show enlarged images in each picture. Right panels: Quantification of the number of Gdnf and S100β double-positive cells (a) and S100a10 and S100β double-positive cells (b). Each point is a data from an individual image. Horizontal bars represent the mean ± SEM of n = 12 (a) or 9 (b) images per group. *p < 0.05 and **p < 0.01 by two-way ANOVA followed by the Tukey–Kramer post hoc test. Scale bars, 10 μm

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Journal of Neuroinflammation

ISSN: 1742-2094