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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model

Fig. 9

Reduced MPTP-induced GFAP upregulation in Cx30-deficient mice. a, b GFAP immunostaining of the striatum on day 1 (a) and 7 (b) after injection of WT and Cx30 KO mice with normal saline (NS) or MPTP. c Quantification of Western blot analysis of GFAP protein levels normalised to β-actin levels. d, e GFAP immunostaining (d) and GFAP-positive cell numbers (e) in the SNc in WT and Cx30 KO mice 7 days after injection of NS or MPTP. Data are the mean ± SEM of n = 3 (c) or 4 (e) mice. *p < 0.05, **p < 0.01, and***p < 0.001 by two-way ANOVA followed by the Tukey–Kramer post hoc test. Scale bars, 200 μm (a, b) and 100 μm (d). Blot images are presented in Additional file 1: Figure S11

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