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Table 3 Sensitivity and specificity of outcome of asphyxiated newborns and newborn nonasphyxiated controls

From: Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants

 

HIE grade

Outcome

IL-6 > 77 pg/mL

FasL > 24 pg/mL

IL-6 > 77 pg/mL and/or FasL > 24 pg/mL

IL-6 > 77 pg/mL

FasL > 45 pg/mL

IL6 > 77 pg/mL and/or FasL > 45 pg/mL

True positive

20

27

30

19

19

24

True negative

32

28

27

37

33

32

False positive

2

6

7

3

7

8

False negative

10

3

0

5

5

0

Specificity (%)

94.1

82.4

79.4

92.5

82.5

80.0

Sensitivity (%)

66.7

90.0

100.0

79.2

79.2

100.0

Accuracy (%)

81.3

85.9

89.1

87.5

81.3

87.5

Negative predictive values (%)

76.2

90.3

100.0

88.1

86.8

100.0

Positive predictive values (%)

90.9

81.8

81.1

86.4

73.1

75.0

  1. HIE Hypoxic ischemic encephalopathy
  2. aDeath or Adverse neurological outcome, including delayed neurodevelopment with mental developmental index (MDI) < 85, deafness or blindness, and cerebral palsy or seizure disorder