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Table 3 Sensitivity and specificity of outcome of asphyxiated newborns and newborn nonasphyxiated controls

From: Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants

  HIE grade Outcome
IL-6 > 77 pg/mL FasL > 24 pg/mL IL-6 > 77 pg/mL and/or FasL > 24 pg/mL IL-6 > 77 pg/mL FasL > 45 pg/mL IL6 > 77 pg/mL and/or FasL > 45 pg/mL
True positive 20 27 30 19 19 24
True negative 32 28 27 37 33 32
False positive 2 6 7 3 7 8
False negative 10 3 0 5 5 0
Specificity (%) 94.1 82.4 79.4 92.5 82.5 80.0
Sensitivity (%) 66.7 90.0 100.0 79.2 79.2 100.0
Accuracy (%) 81.3 85.9 89.1 87.5 81.3 87.5
Negative predictive values (%) 76.2 90.3 100.0 88.1 86.8 100.0
Positive predictive values (%) 90.9 81.8 81.1 86.4 73.1 75.0
  1. HIE Hypoxic ischemic encephalopathy
  2. aDeath or Adverse neurological outcome, including delayed neurodevelopment with mental developmental index (MDI) < 85, deafness or blindness, and cerebral palsy or seizure disorder