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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Levels of ADAM10 are reduced in Alzheimer’s disease CSF

Fig. 3

Decreased levels of mature ADAM10 species in AD CSF samples. a Representative blot of ADAM10 species immunoreactive to an ectodomain antibody in the CSF samples from 27 AD patients and 26 age-matched non-AD controls (NADC). Arrow head indicates a non-specific band. b Densitometric quantification of ADAM10 immunoreactivity from the 55 kDa species attributed to the mature form (ADAM10f), the truncated 50 kDa (sADAM10), and the 80 kDa immature form (proADAM10). Equal volumes of CSF were loaded in each lane and Ponceau staining served to monitor potential loading inaccuracies (none of the major bands detected by Ponceau staining displayed significant differences between groups). c The ratio derived from the immunoreactivity for the mature 50 and 55 kDa bands relative to that for the immature 80 kDa band estimated in each sample [(50 kDa + 55 kDa)/80 kDa] is also shown. Data are presented as means ± SEM: *p ≤ 0.005

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