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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation

Fig. 1

Adam10 expression is decreased in the hippocampus of TLE mice. a Representative images showing the expression of Adam10 protein in the CA1, DG, striatum, and cortex area of the mouse brain by DAB staining (n = 4). b, c Western blots and quantification of Adam10 protein level in Ctrl and days 1, 7, 14, and 28 post-SE mice (F4,20 = 7.40, p = 0.020, 14 days vs Ctrl; p = 0.006, 28 days vs Ctrl) (n = 5). d Representative images of the immunostaining of Adam10 in the hippocampal CA1 region of the Ctrl and day 28 post-SE mice, respectively. e Bar graphs showing the quantification of Adam10-positive cells in Ctrl and day 28 post-SE mice (p = 0.02) (n = 4). *p < 0.05 and **p < 0.01 compared with Ctrl mice, unpaired two-tailed Student’s t test, and one-way ANOVA. Scale bar = 100 μm in a and 20 μm in d

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