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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation

Fig. 2

Inflammation-related proteins and cytokines are increased in the hippocampus of TLE mice. a Western blotting showing the protein levels of the inflammation-related proteins iNOS and COX-2 and NF-κB in the hippocampus of Ctrl and 7, 14, and 28 days post-SE mice. bd Bar graphs showing the quantification of iNOS (F3,16 = 9.60, p = 0.004, 14 days vs Ctrl; p = 0.001, 28 days vs Ctrl), COX-2 (F3,16 = 17.02, p < 0.001, 14 days vs Ctrl; p < 0.001, 28 days vs Ctrl), and NF-κB (F3,16 = 7.76, p = 0.025, 14 days vs Ctrl; p = 0.018, 28 days vs Ctrl), which are represented as the intensity ratios of these proteins to β-actin (n = 5). e, f Bar graphs showing the concentration of IL-1β (F3,16 = 10.32, p = 0.004, 14 days vs Ctrl; p = 0.002, 28 days vs Ctrl) and TNF-α (F3, 16 = 11.41, p = 0.027, 14 days vs Ctrl; p < 0.001, 28 days vs Ctrl) in the hippocampus of Ctrl and 7, 14, and 28 day post-SE mice, which were detected by ELISA (n = 5). *p < 0.05, **p < 0.01, ***p < 0.001, and one-way ANOVA

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