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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial

Fig. 6

RAS modulation reduced apoptotic cell death post-stroke. a Representative 20× immunofluorescent images depicting TUNEL positive (green stained) cortical cells with red propidium iodide nuclear staining, scale bar 50 μm. b Animals subjected to tMCAO had a significantly greater number of tunnel positive cells in the ischemic hemisphere than shams F(4,7) = 4.373, P = 0.0437. Cell death was greatly reduced in animals treated long-term with C21 and candesartan (n = 3–4 animals/group, error bars indicate SEM). Statistical significance for post hoc comparisons between groups using Tukey’s multiple comparison procedure are denoted by *P < 0.05 to indicate a difference from unstroked/sham animals

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