Skip to main content

Table 1 Clinical parameters of EAE in mice treated with IgG2a isotype control or anti-mCD52 antibody

From: Anti-CD52 antibody treatment depletes B cell aggregates in the central nervous system in a mouse model of multiple sclerosis

 

EAE onset (days after immunization)

Score at treatment onset

Disease duration before treatment

Final score

Score difference

Treatment at the peak of EAE

 Isotype

  n = 5

15.40 ± 1.40

2.75 ± 0.08

5.20 ± 1.83

2.15 ± 0.22

0.60 ± 0.15

 Anti-mCD52

  n = 4

20.25 ± 1.11

2.94 ± 0.36

2.75 ± 1.11

1.50 ± 0.54

1.44 ± 0.21

  p value

0.02

0.83

0.37

0.32

0.02

Treatment after ~ 60 days of EAE

 Isotype

  n = 14

16.29 ± 0.85

2.61 ± 0.09

61.57 ± 1.27

2.43 ± 0.15

0.18 ± 0.10

 Anti-mCD52

  n = 18

15.28 ± 0.85

2.57 ± 0.11

61.72 ± 1.20

2.47 ± 0.13

0.10 ± 0.07

  p value

0.29

0.59

0.95

0.85

0.47

  1. All data are shown as mean values ± SEM. Mann-Whitney test was used to determine statistical significance
Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094