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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Effect of tumor necrosis factor-α on the expression of the ammonia transporter Rhcg in the brain in mice with acute liver failure

Fig. 3

Representative images of hematoxylin and eosin-stained mouse liver tissue specimen (× 200 original magnification). Severe hepatocyte swelling, congestion, and focal necrosis (arrows) were observed 6 h post LPS/D-GalN injection. Massive or submassive necrosis of liver tissues (red areas) was observed at 9 and 12 h post LPS/D-GalN injection and at 12 h post TNF-α/D-GalN injection. Only mild-to-moderate hydropic degeneration of hepatocytes (arrows) was observed in D-GalN and LPS controls. Mice in the anti-TNF-α group showed only hydropic degeneration of hepatocytes or focal-hepatonecrosis (arrows). Scale bar 10 μm. N.S. normal saline, D-GalN d-galactosamine hydrochloride, LPS lipopolysaccharide, TNF-α tumor necrosis factor-alpha

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