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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Human Alzheimer’s disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology

Fig. 2

Localization of TREM2 and Cd33 around amyloid-beta (Aβ) plaques in the aged TgCRND8 mouse. Brain slices were prepared from 35-week-old wild-type and TgCRND8 mice and processed for amyloid-beta immunohistochemistry (6E10 labeling, magenta) combined with TREM2 (panel a) or CD33 (panel b) in situ hybridization via RNAScope (brown). Visualization of TREM2 and Cd33 confirms their associated expression pattern with Aβ pathology, supporting the rationale for laser capture microdissection of Thio-S-labeled plaques for transcriptome-wide RNA sequencing. Representative images show section sampling for LCM and RNA seq (c, d). Images show Iba1 (brown) and 6E10 (magenta) immunostainings. Scale bars, 50 and 100 μm

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Journal of Neuroinflammation

ISSN: 1742-2094