Fig. 5
Overlap of TgCRND8 progression signature and plaque-niche signature. a, b Heatmap showing log10 ratio values from each whole cortex sample (a) or each LCM sample (b) for genes reported to be expressed higher (> 1.5 fold, p < 1e-5) in the DAM population [37]. Samples are ordered manually by genotype and age as indicated. Genes are ordered by agglomerative clustering. c Venn diagram depicting number of genes in common between the Tg576/TgCRND8 whole cortex signatures (p < 0.001, any age) and the genes expressed higher (> 1.5 fold, p < 1e-5) in the DAM cells. d Venn diagram depicting number of genes in common between the TgCRND8 LCM plaque signature (p < 0.001) and the genes expressed higher (> 1.5 fold, p < 1e-5) in the DAM population