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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke

Fig. 5

HBHP decreased the BBB permeability in tPA-treated MCAO rats. a Representative images of Evans blue leakage from 4.5 h MCAO rats. The contents of Evans blue leakage were measured and expressed as microgram per gram brain. *P < 0.05, **P < 0.01; n = 4–6. b Immunofluoresence staining with IgG antibody (red) in the cerebral cortex and striatum from 4.5 h MCAO rats. The leaked IgG was quantified. Scale bar = 200 μm. **P < 0.01, n = 3–4. c Western blot and quantified data of occludin in ischemic ipsilateral hemispheres from 4.5 h MCAO rats. *P < 0.05, **P < 0.01; n = 4. Data were shown as mean ± SD

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