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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression

Fig. 5

K284-6111 inhibits NF-κB translocation in microglial BV-2 cells and cultured astrocytes. The cultured microglial BV-2 cells (a) and cultured astrocytes (b) were incubated with anti-p65 (red) and DAPI staining (blue). Phosphorylation of IκB, and p50 and p65 translocation were detected by Western blotting using specific antibodies in microglial BV-2 cells (c) and cultured astrocytes (d). Each value under the bands is mean ± S.D. from three experiments (c, d). #Significantly different from control group (p < 0.05). *Significantly different from LPS-treated group (p < 0.05)

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Journal of Neuroinflammation

ISSN: 1742-2094