Fig. 5From: High-dose intravenous immunoglobulins reduce nerve macrophage infiltration and the severity of bortezomib-induced peripheral neurotoxicity in ratsIVIg reduce BTZ-induced heat hyperalgesia. Paw withdrawal latencies of treated and control rats after BTZ treatment are shown. The protective effect of IVIg was observed in the preventive group already from the fifth week after the beginning of the study, while the therapeutic effect of IVIg appeared after 7 weeks (i.e., after the second IVIg infusion in this group). Data are reported as mean ± SEM. *p < 0.01 vs BTZBack to article page