Fig. 8

Effects of IVIg treatment in inflammatory infiltration in peripheral nerves. a Immunohistochemistry for CD68: After 3 and 8 weeks of BTZ treatment, both sciatic and caudal nerves show a massive macrophage infiltration which is almost completely abrogated by the preventive co-treatment with IVIg (BTZ + IVIg 3; BTZ + IVIg 8). In the therapeutic setting (BTZ + IVIg 4), a milder reduction of CD68⁺ infiltrating cells was achieved in both sciatic and caudal nerves. Scale bar 50 μm. b Representative immunohistochemistry for iNOS and ARG1 after 3 weeks of BTZ treatment. Most infiltrating macrophages (CD68+) are iNOS⁺ pro-inflammatory M1 type while a very limited amount of them are ARG1+ anti-inflammatory M2 type. Scale bar 50 μm