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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway

Fig. 2

Temporal profiles of IR-induced alteration in p53 and PUMA protein levels and neurological assessments. a Representative western blots of p53 and PUMA levels during the 48-h reperfusion period. b and c Quantification of the integrated intensities of p53 and PUMA bands. Data are expressed as the mean ± SEM. The relative protein expression was normalised to that of the sham group. *P < 0.05, versus the sham group. d Neurological assessments were scored using modified Tarlov criteria at 12-h intervals during 48 h of reperfusion. e Individual assessments of each rat at the indicated time points. Each symbol represents one mouse. The bar represents the median. Data are expressed as the mean ± SEM. n = 6 in each group. *P < 0.05, versus the sham group

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Journal of Neuroinflammation

ISSN: 1742-2094