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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Inhibiting aberrant p53-PUMA feedback loop activation attenuates ischaemia reperfusion-induced neuroapoptosis and neuroinflammation in rats by downregulating caspase 3 and the NF-κB cytokine pathway

Fig. 7

Effects of si-PUMA and PFT-α on blood-spinal cord barrier (BSCB) integrity after IR. a Representative images of IR-induced BSCB breakdown as measured by EB extravasation, which was visualized as red fluorescent spots under a microscope. b Quantification of EB content in the injured spinal cord presented as microgram per gram tissue. c Quantification of EB fluorescence intensity (INT/mm2). d Quantification of spinal water content (%). Data were obtained from three independent experiments and expressed as the mean ± SEM. *P < 0.05, versus the sham group. *P < 0.05, versus the IR group

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Journal of Neuroinflammation

ISSN: 1742-2094