Table 1 Relative weight change, clinical scores and bacterial CSF titres in infant rats with pneumococcal meningitis (n = 156) and uninfected controls (n = 24) during the acute phase of the disease. Activity scores represent 1 = coma; 2 = does not turn upright; 3 = turns upright within 30 s; 4 = minimal ambulatory activity, turns upright in < 5 s; and 5 = normal. Weight change describes percentage of weight gain compared to weight at time of infection. Bacterial titre depicts colony-forming units (CFU) per millilitre CSF at 18 hpi. Data represent mean ± SD. hpi hours post infection, PM pneumococcal meningitis, Cro ceftriaxone, Dap daptomycin

From: Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis